Relaxaderm Advance is an injection-FREE wrinkle relaxer with the power of Dermatox-63, an exclusive combination of active ingredients synergistically formulated to visibly reduce the appearance of wrinkles and expression lines. With its added wrinkle plumping action, crevices are plumped out from the inside, making skin look firmer and smoother, and you look younger! Directions for use: After cleansing, gently massage evenly over face and neck. Follow with daily or nightly moisturiser. For best results use twice daily, morning and evening.